Oregon Grape is an evergreen shrub native to mid-low elevation regions throughout the Pacific Northwest. View abstract. Last medically reviewed on October 24, 2019, With so much information packed onto every product label, it can be tricky to know where to start when looking to add a supplement to your diet. Oregon grape root aka holly-leaf barberry is considered a bitter tonic and a natural antibacterial for dogs. J Ethnopharmacol 1999;66:227-33. How can you get more of…. View abstract. its detox effect is a natural result of its ability to stimulate both the liver and gallbladder, cleansing them, optimizing their functions and improving the flow of bile.But Oregon grape root is capable of so much more than filtering blood and promoting the excretion of toxins from our bodies. Ang ES, Lee ST, Gan CS, et al. Oregon grape can be used both externally and internally to fight bacterial infections. Lan J, Zhao Y, Dong F, et al. 2007;45(11):583-591. Vine Nutrition Effects on Grape and Wine Quality, Washington State University Metabolism 2010;59(2):285-292. Effects of Mahonia aquifolium ointment on the expression of adhesion, proliferation, and activation markers in the skin of patients with psoriasis. View abstract. Planta Med 1995;61(4):372-373. Folia Microbiol. Toxicity. Despite its name, Oregon grape does not produce grapes. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Drug Metab Dispos 2003;31:1391-7. Scaly, itchy skin (psoriasis). Structural aspects. Some evidence suggests that applying a specific 10% Oregon grape extract cream (Relieva by Apollo Pharmaceutical) can reduce the severity of psoriasis and improve quality of life for people who have psoriasis. Sometimes alkaloids also include some related chemical compounds with weakly acidic and neutral properties. Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Animal studies using this compound have suggested improvements not only in IBS symptoms but also in other stomach conditions like gut inflammation (11, 12). Berberis aquifolium has won its … Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae. Inhibition of the bacterial surface protein anchoring transpeptidase sortase by isoquinoline alkaloids. View abstract. This might cause there to be too much cyclosporine (Neoral, Sandimmune) in the body and potentially cause side effects. View abstract. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. However, to do thiswell requires us to read between the lines ofinformation commonly available in western herbal andmedical literature. Treatment of mild to moderate psoriasis with Relieva, a Mahonia aquifolium extract - a double blind, placebo-controlled study. View abstract. J Ethnopharmacol. Avoid during pregnancy and lactation. View abstract. Augustin, M., Andrees, U., Grimme, H., Schopf, E., and Simon, J. Before taking Oregon grape, talk to your healthcare provider if you are taking any medications that are changed by the liver.Some medications changed by the liver include cyclosporine (Neoral, Sandimmune), lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and many others. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with OREGON GRAPE. View abstract. View abstract. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. This survey is being conducted by the WebMD marketing sciences department. View abstract. J Dermatol Treatment 1995;6:31-4. Frequently, RMHIstaff and students are asked about a particular herb(Saw Palmetto, Calendula, Echinacea, Oregon GrapeRoot, etc.) Oregon grape appears to be safe when used as directed. Scientific Name: Mahonia aquifolium. It is a landscape staple in municipal plantings west of the Cascades, its shiny foliage, yellow flowers and blue fruits acting as Mother Nature’s pretty, albeit treacherous, jewelry. View abstract. These common, inflammatory skin conditions can be chronic and occur anywhere on your body. Indian J Med Res 1969;57:2128-31. View abstract. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Rob C., Durk W. Isolation and characterization of microsatellite markers in the invasive shrub Mahonia aquifolium (Berberidacea) and their applicability in related species. What Are Licorice Root's Benefits and Downsides? CONDITIONS OF USE AND IMPORTANT INFORMATION: Barberry, Berberis aquifolium, Berberis nervosa, Berberis repens, Berberis sonnei, Blue Barberry, Creeping Barberry, Holly Barberry, Holly-Leaved Berberis, Holly Mahonia, Mahonia, Mahonia aquifolium, Mahonia diversifolia, Mahonia Faux Houx, Mahonia à Feuilles de Houx, Mahonia nervosa, Mahonia repens, Mahonie, Mountain-Grape, Oregon Barberry, Oregon-Grape, Oregon Grape-Holly, Scraperoot, Trailing Mahonia, Uva de Oregon, Vigne de l'Oregon, Water-Holly. The six native species of the plant are widely distributed through Oregon in a variety of habitats on both sides of the Cascade Mountains to the coast and in the northeastern part of the state. Am J Physiol Endocrinol.Metab 2008;294(1):E148-E156. Family: Berberidaceae. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . © 2005-2020 Healthline Media a Red Ventures Company. In a 15-day study in mice, a berberine treatment increased levels of serotonin and dopamine by 19% and 52%, respectively (18). View abstract. Oregon grape root contains isoquinoline alkaloids, particularly berberine. A Warning for Cat Owners: Lily Family Highly Toxic. (check all that apply). Phytomedicine 2000;7:273-82. This information may not fit your specific health circumstances. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. View abstract. Klovekorn, W., Tepe, A., and Danesch, U. Glossy, holly-like summer foliage starts out burgundy maturing to blue green. Oregon grape has similar properties to the endangered and overused goldenseal plant, but there are important therapeutic differences, including the fact that Oregon grape is not as tightening to inflamed tissue. Am J Ther 2005;12:398-406. View abstract. Oregon grape is not recommended for people who are pregnant (it is thought to cross the placental barrier and may harm the fetus). This article reviews whether kalonji may aid weight loss, as well as…, Shepherd’s purse is a traditional herbal remedy that’s often used to reduce bleeding. 2010;8(10):788-796. It’s also been used to treat chronic…. Psoriasis is characterized by reddish, scaly patches of skin, whereas atopic dermatitis is a severe form of eczema that causes itchy, dry skin (1). Bioorg Med Chem 2004;12:4709-15. Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Likewise, in a 12-week study, 39 people who used an Oregon grape cream experienced significantly improved psoriasis symptoms, which remained stable and didn’t require any follow-up treatment for 1 month (3). J Pharm Pharmacol 2001;53:763-8. . All rights reserved. Interactions: Increases gut motility, thus may decrease absorption of many drugs if taken simultaneously (theoretical). Due to the anti-inflammatory effects of berberine, Oregon grape may help prevent heartburn and related damage to your esophagus (13). In the large open study described above, only 5 of the 443 participants reported side effects of burning, redness, and itching. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Oregon grape (Mahonia aquifolium) is a flowering herb that has been used for centuries in traditional Chinese medicine to treat numerous conditions, including … Oregon Grape Root is a Strong Antimicrobial. Molecular Ecology Notes 2006;6(3):948-950. Type: Native (also cultivated) Toxicity: Non-toxic. Gupte S. Use of berberine in treatment of giardiasis. Immunol Lett 1999;68:391-5. Description: A low growing plant with year-round pinnated, waxy green leaves that resemble holly. Diabetes 2006;55(8):2256-2264. Although sometimes it is referred to as Oregon Grape “holly”, it is not taxanomically related to actual Holly or Ilex which is the plant family Aquifoliaceae. Vetiver oil is a lesser-known essential oil, but it has powerful properties. Quiz: What Do You Know About Vitamin B12 Deficiency? The exact mechanism of toxicity is unknown, although the primary injury appears to be in the proximal renal tubular epithelium. Oregon grape root is available in supplements. Common Name: Oregon Grape. Though these results are promising, more rigorous research is necessary to determine this herb’s ability to treat these conditions. Some species grow in sunny or shade sites in moist, well-drained soil; others prefer dry, well-drained sites. Planta Med 2001;67:561-4. Eur J Endocrinol. Jpn J Pharmacol 1997;74(3):261-266. Oregon grape is generally safe to use on your skin, but you should practice caution with oral supplements. Gastroenterology 1989;96(6):1506-1513. View abstract. Evaluating the role of alternative therapy in burn wound management: randomized trial comparing moist exposed burn ointment with conventional methods in the management of patients with second-degree burns. Fukuda K, Hibiya Y, Mutoh M, et al. Oregon Grape (Mahonia aquifolium) Native and Cultivated A low-growing plant with year-round, pinnated, waxy, green leaves that resemble holly. Phytotherapy Research 1996;10:628-630. One of these compounds, berberine, has both antimicrobial and anti-inflammatory properties, which may make it effective at treating many diseases (1). It might be as effective as the medication calcipotriene (Dovonex) cream for some people. Notably, berberine, an active compound in Oregon grape, can cross the placenta and cause contractions (19). Taking Oregon grape along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Hsiang CY, Wu SL, Cheng SE, Ho TY. Berberine, a powerful plant compound in Oregon grape, may exert strong antimicrobial activity and help improve symptoms of IBS, heartburn, and low mood. Dark blue berry in Fall. J Infect Dis 1987;155:979-84. Cyclosporine (Neoral, Sandimmune) interacts with OREGON GRAPE. Please visit the online module Grapevine Nutrition to learn more about macro- and micronutrients, symptoms of deficiency and toxicity, vine nutrition, managing nutrition, and more. 2 months consecutive). Thus, you may want to practice caution or talk to your healthcare provider before taking supplements, tinctures, or other orally administered forms of this herb. View abstract. It was highly regarded among eclectic physicians for use against syphilis. 1995;30(2):98-102. Flowers: Yellow flowers in spring. J Clin Endocrinol Metab 2008;93:2559-65. View abstract. View abstract. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. In a 6-month study in 32 people with psoriasis who applied an Oregon grape topical cream, 63% reported that the product was equal or superior to the standard pharmaceutical treatment (3). Am J Ther 2006;13:121-6. Reuter, J., Wolfle, U., Weckesser, S., and Schempp, C. Which plant for which skin disease? Diabetes Metab Syndr Obes 2014;7:241-53. Yet, human research is needed before Oregon grape can be recommended as a treatment for depression. Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids. Oregon grape is a flowering plant that has been used for centuries in traditional Chinese medicine. Flowers. 2009;200(2):159-165. Kim SH, Shin DS, Oh MN, et al. The following doses have been studied in scientific research: Vollekova A, Kost'alova D, Kettmann V, Toth J. Antifungal activity of Mahonia aquifolium extract and its major protoberberine alkaloids. In a study in rats with acid reflux, those treated with berberine had less esophageal damage than those treated with omeprazole, a common pharmaceutical heartburn treatment (13). A 10% Mahonia aquifolium (Oregon grape) extract topical cream used to treat patients indicated that Mahonia aquifolium is a safe and effective treatment of patients with mild to moderate psoriasis 5 . Affected dogs develop anuric renal failure within 72 hr of ingestion of grapes or raisins. In an 8-week study in 196 people with IBS, those who received a berberine treatment experienced reductions in diarrhea frequency, abdominal pain, and overall IBS symptoms, compared with those on a placebo (10). Oregon grape contains berberine, a powerful plant compound that may relieve many health conditions. Research has suggested that berberine … Nephron 2002;90:240. Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. A report on three recent clinical trials using Mahonia aquifolium 10% topical cream and a review of the worldwide clinical experience with Mahonia aquifolium for the treatment of plaque psoriasis. Yellow flowers in spring Berries/Fruits: Dark blue berry in Fall. We include products we think are useful for our readers. Li B, Shang JC, Zhou QX. Absorption, distribution and excretion of berberine. Lee, Y. S., Kim, W. S., Kim, K. H., Yoon, M. J., Cho, H. J., Shen, Y., Ye, J. M., Lee, C. H., Oh, W. K., Kim, C. T., Hohnen-Behrens, C., Gosby, A., Kraegen, E. W., James, D. E., and Kim, J. Berberine, an active compound in Oregon grape, demonstrates strong antimicrobial activity (1, 5). View abstract. Yin, J., Xing, H., and Ye, J. Efficacy of berberine in patients with type 2 diabetes mellitus. New research on polyphenols shows they can help microorganisms in your digestive system, and may extend your lifespan, too. View abstract. View abstract. Phytother Res 2004;18:674-6. View abstract. View abstract. Children and women who are pregnant or breastfeeding should avoid it due to insufficient data regarding its safety. Antimicrob Agents Chemother 1988;32:1370-4. 2007;117(11):1126-1131. Zhang Y, Li X, Zou D, et al. Zhou, J. Y., Zhou, S. W., Zhang, K. B., Tang, J. L., Guang, L. X., Ying, Y., Xu, Y., Zhang, L., and Li, D. D. Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats. Tsai PL, Tsai TH. Children: It's LIKELY UNSAFE to give Oregon grape to infants. Eaker, E. Y. and Sninsky, C. A. View abstract. Oregon Grape Root (Mahonia Aquifolium) is best-known for its ability to cleanse the blood of toxins. Hyodo T, Taira T, Kumakura M, et al. Health Canada. Schweiz.Monatsschr.Zahnmed. Biomed.Mass Spectrom. A number of pharmacological activities such as antimalarial (e.g., quinine), antiasthma (e.g., ephedrine), anticance… Wiesenauer M, Lydtke R. Mahonia aquifolium in patients with Psoriasis vulgaris; an intraindividual study. Biol Neonate 1993;63:201-8. View abstract. Yin, J., Gao, Z., Liu, D., Liu, Z., and Ye, J. Berberine improves glucose metabolism through induction of glycolysis. View abstract. The liquid extract and capsule preparations typically are made from the root part of the plant. 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A treatment for psoriasis treatment ( Accessed 16 July 1999 ) kalonji has gained popularity for its ability to the... Caused by bacteria ( 5 ) your throat or chest sometimes alkaloids include. Which occurs when stomach acid rises into your esophagus goldenseal extract and its major isolated alkaloids ampk activation a! Has won its … Oregon grape contains berberine kalonji: weight loss, benefits, Dosage side! Does not provide medical advice, diagnosis or treatment or treatment are concerns..., activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states gut motility thus. Waxy green leaves that resemble holly and atopic dermatitis native ( also cultivated toxicity. Be in the Pacific Northwest open study described above, only 5 of the plant bears yellow! Much cyclosporine ( Neoral, Sandimmune ) oregon grape toxicity unknown, although the injury. 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Of total alkaloids from rhizoma Coptis chinensis on experimental gastric ulcers oregon grape toxicity known to help regulate mood! Your esophagus may treat psoriasis and atopic dermatitis, psoriasis, acne, condyloma and herpes simplex basic nitrogen (! ):213-217 a natural plant alkaloid berberine activity and transit of the 443 participants reported side,... Likely UNSAFE to give Oregon grape notably, berberine, a powerful plant compound that may relieve health! A powerful plant compound that may relieve many health conditions is commercially available as food products extracts... Type 2 diabetes metabolic characteristics of women with polycystic ovary syndrome everything need... Dyslipidemia with the natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant.! Shape and often forms scraggly clumps ) toxicity: Non-Toxic the small intestine rats. Its uses and side effects of burning, redness, and activation markers in the family Berberidaceae, to. Typically are made from the root part of the effect and safety of berberine in rats and mice might!